0. DOCID:7786 SCORE: 0.00331753552260543
DOCNO: 652985
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: pathology
AUTHOR: H Creutzig H
PUBTYPE: Journal Article
JOURNALTITLE: Der Radiologe.
COUNTRY: GERMANY, WEST
TITLE: [Staging of patients with carcinoma of the breast by bone scans? [author's transl)]
PUBDATE: 19780501
Bone scans were performed in 170 patients with widespread breast cancer and metastases which were confirmed by the clinical course. In 82% a positive x-ray and in 95% a positive bone scan could be demonstrated. In 43 patients without bone metastases the ratio of false positive scans was 5%. Seventeen out of 50 patients with early cancer had abnormal scans. In 12 cases there were metastases proven by follow-up of at least 18 months. Assuming an incidence of 25% for bone metastases in patients with early breast cancer, bone scans with a sensitivity and specificity of 95% will be valid in staging. To validate this high incidence we investigated a second group of 97 patients with early cancer in a prospective study: in only 3 cases there was an abnormal scan. Using this low incidence bone scanning is calculated to be not valid for staging of breast cancer.


1. DOCID:23519 SCORE: 0.00298148239942095
DOCNO: 9627713
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle Proteins
DESCRIPTOR: Tumor Suppressor Proteins
QUALIFIER: genetics
AUTHOR: A Kamb A
AFFILIATION: Myriad Genetics, Inc., Salt Lake City, UT 84108, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research.
COUNTRY: UNITED STATES
TITLE: Human melanoma genetics.
PUBDATE: 19960401
Melanoma is an important human cancer, the etiology of which has been the subject of much study. Recently a gene for familial melanoma, MLM, has been mapped and isolated. This gene encodes the cell-cycle regulator p16 and is mutated in a variety of sporadic human cancers in addition to melanoma. The isolation of MLM answers some questions in the area of melanoma biology, but raises others. Identification of p16 and other genes that contribute to melanoma development may be viewed as one step in the attempt to understand, diagnose, and treat this malignant disease.


2. DOCID:3091 SCORE: 0.0029248542899575
DOCNO: 986259
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Galactosemias
QUALIFIER: blood
QUALIFIER: analysis
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: J E Mrochek JE
AUTHOR: S R Dinsmore SR
AUTHOR: D C Tormey DC
AUTHOR: T P Waalkes TP
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Protein-bound carbohydrates in breast cancer. Liquid-chromatographic analysis for mannose, galactose, fucose, and sialic acid in serum.
PUBDATE: 19760901
We describr high-resolution chromatographic analysis for protein-bound sialic acid in serum, with use of a cerate oxidimetric detector. Values for sera from normal women averaged 680.5 mg/liter, with a coefficient of variation of 23%. Including data obtained by previously developed chromatographic procedures for protein-bound mannose, galactose, and fucsoe, we assessed sera from breast-cancer patients whose malignancy had been categorized as either stable, responsive, or progressive (based on clinical observations spaced from two to five months apart). All of 12 responsive patients had decreases of protein-bound fucose averaging 34.5% (SD, 16.1) and all of 10 patients with progressive disease had increases averaging 38.3% (SD 21.5). Changes in fucose averaged less than 6.7% (SD, 4.9) for eight patients with clinically stable breast cancer. Changes in protein-bound mannose, galactose, and sialic acid did not correlate as well as did fucose with the clinical disease status of the patients.


3. DOCID:3447 SCORE: 0.00283961804650379
DOCNO: 1203838
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
AUTHOR: C R Smart CR
AUTHOR: L B Townsend LB
AUTHOR: W J Rusho WJ
AUTHOR: H J Eyre HJ
AUTHOR: J M Quagliana JM
AUTHOR: M L Wilson ML
AUTHOR: C B Edwards CB
AUTHOR: S J Manning SJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Phase I study of ftorafur, an analog of 5-fluorouracil.
PUBDATE: 19750701
Ftorafur, a furanyl analog of 5-fluorouracil (5-FU), is reported to be five to six times less toxic and possibly more effective in cancer of the breast and colon than 5-FU. The drug was synthesized, formulated, and utilized in toxicologic studies, and then in 24 patients with advanced incurable malignancies. When Ftorafur is given by intravenous push, it results in immediate flushing, dizziness, nausea, retching, and in some cases transient hypotension. These immediate side effects are largely eliminated by administering the drug slowly by infusion. In patients, 60 mg/kg of Ftorafur given i.v. daily for up to 10 days resulted in mild toxicity. However, 80 mg/kg given i.v. daily for 7 days resulted in severe toxicity, with nausea, vomiting, stomatitis, leukopenia, and thrombocytopenia. These studies confirm those of the Russian investigators as to toxicity and dosage, even with a different method of administration more convenient for therapy. Phase II studies are presently being carried out to compare the effectiveness of Ftorafur and 5-FU.


4. DOCID:15608 SCORE: 0.00268391444086744
DOCNO: 3062286
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Heart Transplantation
QUALIFIER: chemically induced
QUALIFIER: surgery
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: S Ballhaus S
AUTHOR: G Grevers G
AFFILIATION: HNO-Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Laryngologie, Rhinologie, Otologie.
COUNTRY: GERMANY, WEST
TITLE: [Laryngeal cancer in immunosuppressive therapy with cyclosporin A]
PUBDATE: 19880701
As a serious side effect of immunosuppressive therapy following organ transplantation, the incidence of malignancies shows a significant threefold increase compared with the age-matched general population. Under treatment with conventional immunosuppressive drugs (azathioprine, steroids and antilymphocyte globulin) patients are supposed to be susceptible to skin and lip cancers (40%) whereas the recently introduced new immunosuppressive drug cyclosporine A shows a comparable incidence of non-Hodgkin lymphomas (41%) and the patients seem to develop more potentially life threatening tumours of internal organs. In the present paper we report on a case of laryngeal carcinoma following immunosuppressive treatment with cyclosporine A 10 months after heart transplantation.


5. DOCID:26495 SCORE: 0.00268013360597462
DOCNO: 10700909
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: T Sasaki T
AFFILIATION: Dept. of Chemotherapy, Tokyo Metropolitan Komagome Hospital.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Combination of levofolinate calcium and 5-fluorouracil]
PUBDATE: 20000201
It has been determined that in the combination of Leucovorin (LV) and 5-fluorouracil (5-FU), LV potentiates the cytotoxic effect of 5-FU based on biochemical modulation. Many data suggest that LV/5-FU is a very effective combination, and most clinicians worldwide now regard it as the standard therapy for colorectal cancer. In Japan, clinical examinations of this combination using Levofolinate calcium (I-LV) have shown its effectiveness, and I-LV/5-FU for gastric and colorectal cancer was authorized by the Ministry of Public Welfare in Oct. 1999.


6. DOCID:27996 SCORE: 0.002512246047023
DOCNO: 9679358
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Education, Medical, Continuing
DESCRIPTOR: Health Knowledge, Attitudes, Practice
DESCRIPTOR: Program Evaluation
QUALIFIER: education
QUALIFIER: complications
QUALIFIER: therapy
AUTHOR: C Hines C
AUTHOR: J Bingham J
AUTHOR: N Muirden N
AUTHOR: M Beavis M
AFFILIATION: Peter MacCallum Palliative Care Grants Program. hine0014@baggins.cc.flinders.edu.au
PUBTYPE: Journal Article
JOURNALTITLE: Australian family physician.
COUNTRY: AUSTRALIA
TITLE: Evaluation of a cancer pain education program for general practitioners.
PUBDATE: 19980701
OBJECTIVE: To evaluate a cancer pain education program. METHOD: Participants in the program completed an evaluation form covering various aspects of the program's design. RESULTS: All participants who completed the program were glad that they had done so. The most and least useful aspects are included in the article. Participants were satisfied with the program and eager to participate in similar ones. CONCLUSION: The education program was both successful at improving participants' knowledge of cancer pain management and provided in a manner acceptable to the participants. Ideas for future similar projects are included.


7. DOCID:3951 SCORE: 0.00250412129350623
DOCNO: 1117595
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: J Utsunomiya J
AUTHOR: H Gocho H
AUTHOR: T Miyanaga T
AUTHOR: E Hamaguchi E
AUTHOR: A Kashimure A
PUBTYPE: Journal Article
JOURNALTITLE: The Johns Hopkins medical journal.
COUNTRY: UNITED STATES
TITLE: Peutz-Jeghers syndrome: its natural course and management.
PUBDATE: 19750201
Two hundred and twenty-two patients with Peutz-Jeghers syndrome were ascertained in Japan between 1961 and 1974 through two nationwide surveys, medical literature, and personal examinations. Genetic analysis was made of this group as well as 102 follow-up cases. The average age at diagnosis was 23 in males and 26 in females, with male to female ratio of 1:1.13. Presenting complaints of 170 patients included obstruction (42.8 per cent of patients), abdominal pain (23.4 per cent), rectal bleeding (13.5 per cent), extrusion of polyp (7.2 percent). Diagnosis of 52 patients was based on melanin pigmentation. Intussusception occurred in 46.9 per cent of the patients, most often in the small intestine. Polyps occurred in the stomach in 108 patients (48.6 per cent), small intestine, 142 patients (64 per cent), colon, 118 patients (53.2 per cent) and rectum, 71 patients (32 per cent). Among the 222 patients, cancer was histologically verified in 28. Fifteen early cancers occurred (3 gastric, 8 small intestine, 4 colon), and 11 advanced cancers (3 gastric, 1 small intestine, 6 colon, and 1 both colon and small intestine). Mortality was lower than in patients with familial polyposis coli but higher than in the general population. Conservative surgical management, planned medical follow-up, and the need for a national registration system are stressed.


8. DOCID:2766 SCORE: 0.00249814451526523
DOCNO: 912870
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: blood
AUTHOR: L M Silverman LM
AUTHOR: G B Dermer GB
AUTHOR: Z A Tökes ZA
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Electrophoretic patterns for serum glycoproteins reflect the presence of human breast cancer.
PUBDATE: 19771101
We describe a group of glycoproteins that are synthesized and released by human breast tumors maintained in organ culture and similar glycoproteins released by a human breast carcinoma cell line (BT-20). The electrophoretic mobility of these glycoproteins on cellulose acetate is consistent with increased glycoprotein-staining material present in the alpha2- to beta-globulin region of serum glycoprotein electropherograms from patients with breast cancer. Moreover, after mastectomy, this glycoprotein material in serum decreases to concentrations seen in a control population of patients with benign breast lesions. Patients with proven metastatic breast cancer have patterns reflecting their clinical status: those who respond to treatment have glycoprotein electropherograms similar to the group of patients with benign breast lesions, while those who do not have increased amounts of alpha2- beta-glycoprotein. We believe serum glycoprotein measurements in breast-cancer patients reflect the presence of glycoproteins that are released by the malignant cells and enter the circulation.


9. DOCID:3095 SCORE: 0.0024546325723032
DOCNO: 1192361
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radioactive Fallout
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: T Ishimaru T
AUTHOR: R W Cihak RW
AUTHOR: C E Land CE
AUTHOR: A Steer A
AUTHOR: A Yamada A
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Lung cancer at autopsy in A-bomd survivors and controls, Hiroshima and Nagasaki, 1961-1970. II. Smoking, occupation, and A-bomb exposure.
PUBDATE: 19751101
The apparent effect of ionizing radiation on lung cancer in A-bomb survivors has not been large enough to still doubts as to its validity. It has seemed essential to determine whether the apparent radiation effect could have resulted from a confounding of heavy smoking and high radiation dose, or if the occupational exposure of high-dose subjects with lung cancer was suggestive of the influence of environmental hazards other than radiation. The available series consists of 204 subjects with lung cancer verified by autopsy, 61 of whom were low-dose (less than 1 rad) and 13 high-dose (200 + rads) subjects. No evidence could be found that the influence of either smoking or occupational exposure upon lung cancer was exerted so as to suggest that the apparent radiation effect is other than real. The study also provides additional evidence of the relationship between lung cancer and smoking in Japanese.


10. DOCID:7439 SCORE: 0.00245161661672291
DOCNO: 634505
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
AUTHOR: C Mor C
AUTHOR: S Orefice S
AUTHOR: F Rocco F
AUTHOR: R Accinni R
AUTHOR: A Bartorelli A
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [Direct radioimmunological determination of plasma CEA in 1704 patients]
PUBDATE: 19780201
An original technique for the direct radioimmunological measurement of plasma CEA has been prepared. Compared to the other in use, this has the advantage of a very low incidence of false positivity. 1704 patients make up the series: the percentage of positivity in 247 suffering from gastroenteric adenocarcinoma was 66.8%, in 60 with lung cancer 30%, in 243 with malignant tumours in various sites 7.4%, in 199 with chronic liver diseases 29.6% while in 598 cases of other non-neoplastic diseases it was only 2.5%. 212 patients who underwent radical surgery for gastroenteric adenocarcinoma were also followed up and the test provided early diagnosis of the clinical re-onset of the neoplastic lesion. It is considered that plasma CEA measurement represents a useful aid to the clinician althouth it cannot be employed at present to screen gastroenteric adenocarcinomas.


11. DOCID:22771 SCORE: 0.00239672124160819
DOCNO: 8906048
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: C W Cummings CW
AFFILIATION: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Outpatient Center, Baltimore, Md, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology--head & neck surgery.
COUNTRY: UNITED STATES
TITLE: Is reengineering of head and neck cancer treatment indicated? Absolutely.
PUBDATE: 19961101
A review of the table of contents of the program for the fourth International Conference on Head and Neck Cancer permits one to conclude that there is high energy in virtually every aspect of either the diagnosis or therapy concerning head and neck cancer. There is, in addition, an emerging interest (in fact, emphasis) on a more global restitution of the head and neck cancer patient, such that rehabilitation, both physical and emotional, as well as a greater acceptance of the benefits of less orthodox methods for treatment can be seen affecting outcomes.


12. DOCID:22752 SCORE: 0.00239671887555038
DOCNO: 7529702
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: epidemiology
AUTHOR: K Hemminki K
AUTHOR: G Pershagen G
AFFILIATION: Center for Nutrition and Toxicology, Karolinska Institute, Stockholm, Sweden.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Cancer risk of air pollution: epidemiological evidence.
PUBDATE: 19941001
Epidemiological studies on the effect of urban air pollution on lung cancer were surveyed. Overall, the studies from many countries point to a smoking-adjusted risk in urban areas over countryside areas that is higher by a factor of up to 1.5. The extent to which urban air pollution contributes to this excess remains unknown. Studies on diesel-exposed occupational groups show that urban air pollution may have a causative role in lung cancer. Model calculations on unit risk factors of known human carcinogens were carried out to rank carcinogens according to their current ambient air concentrations.


13. DOCID:6936 SCORE: 0.00239496651449236
DOCNO: 6777904
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: A Yajima A
AUTHOR: H Higashiiwai H
AUTHOR: A Sato A
AUTHOR: M Watanabe M
AUTHOR: T Mori T
AUTHOR: M Suzuki M
AUTHOR: T Hanyu T
AUTHOR: K Suzuki K
AUTHOR: H Kinii H
AUTHOR: T Moritsuka T
AUTHOR: N Igarashi N
AUTHOR: M Nakano M
AUTHOR: K Nagasawa K
AUTHOR: S Sato S
PUBTYPE: Journal Article
JOURNALTITLE: The Tohoku journal of experimental medicine.
COUNTRY: JAPAN
TITLE: Combination chemotherapy in advanced ovarian cancer.
PUBDATE: 19801001
Among the 95 cases of ovarian cancer treated by us between May, 1975 and August, 1978, only 33 were suitable for complete resection. The remaining 62 cases underwent incomplete resection, followed by F.Q.C. combination chemotherapy (1-(2-tetrahydrofuryl)-5-fluorouracil, carbazilquinone, cytosine arabinoside); 54.8% showed an antitumor response. The median survival time of the responders was 13.2 months, whereas it was 7.4 months for the non-responders. The survival rate after 24 months, however, was 13% and 4%, respectively. Side effects of the drugs, including leucopenia, thrombocytopenia, nausea and vomiting, were found in roughly one half of the cases.


14. DOCID:25764 SCORE: 0.00239209843324997
DOCNO: 10627999
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Electromagnetic Fields
QUALIFIER: radiation effects
AUTHOR: M Babincová M
AUTHOR: P Sourivong P
AUTHOR: D Leszczynska D
AUTHOR: P Babinec P
AFFILIATION: Department of Biophysics and Chemical Physics, Comenius University, Bratislava, Slovakia. babincova@fmph.uniba.sk
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Naturforschung. C, Journal of biosciences.
COUNTRY: GERMANY
TITLE: Activation of hematoporphyrin in alternating magnetic field: possible implications for cancer treatment.
PUBDATE: 19991101
A new mechanism of cell damage by alternating magnetic field with hematoporphyrin is described. C6 glioblastoma cell suspensions were exposed to an alternating magnetic field with frequency 180 kHz up to 60 min in the presence of hematoporphyrin in H2O and in D2O. The results presented suggest that an alternating magnetic field is able to activate hematoporphyrin, and this method may be a basis for cancer treatment.