Activated AMPK stimulates fatty-acid oxidation in muscle Activated TLR4 signalling Activation of BAD and translocation to mitochondria Activation of BH3-only proteins Activation of Chaperone Genes by XBP1(S) Activation of Chaperones by IRE1alpha Activation of NF-kappaB in B Cells Adaptive Immune System Adherens junction ALK1 pathway ALK1 signaling events Alpha6Beta4Integrin Alpha9 beta1 integrin signaling events Alpha-synuclein signaling amb2 Integrin signaling Amoebiasis AMPK inhibits chREBP transcriptional activation activity Androgen-mediated signaling AndrogenReceptor Angiopoietin receptor Tie2-mediated signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation Antiviral mechanism by IFN-stimulated genes AP-1 transcription factor network Apoptosis Arf6 downstream pathway Arf6 signaling events Arf6 trafficking events Asparagine N-linked glycosylation ATM pathway ATR signaling pathway Atypical NF-kappaB pathway Aurora A signaling Axon guidance BCR signaling pathway Beta1 integrin cell surface interactions Beta3 integrin cell surface interactions Biological oxidations BMAL1:CLOCK/NPAS2 Activates Circadian Expression BMP receptor signaling Calnexin/calreticulin cycle Canonical NF-kappaB pathway Canonical Wnt signaling pathway CD28 co-stimulation CD40/CD40L signaling CDC42 signaling events Cell-Cell communication Cell Cycle Cell Cycle, Mitotic Cell junction organization Cell surface interactions at the vascular wall Centrosome maturation Circadian Clock Class I MHC mediated antigen processing & presentation Class I PI3K signaling events Class I PI3K signaling events mediated by Akt C-MYB transcription factor network C-MYC pathway Collagen biosynthesis and modifying enzymes Collagen formation Constitutive PI3K/AKT Signaling in Cancer Coregulation of Androgen receptor activity Costimulation by the CD28 family c-src mediated regulation of Cx43 function and closure of gap junctions CTLA4 inhibitory signaling CXCR4-mediated signaling events Cytokine Signaling in Immune system DAP12 interactions DAP12 signaling Deadenylation-dependent mRNA decay Deadenylation of mRNA Destabilization of mRNA by AUF1 (hnRNP D0) Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) Destabilization of mRNA by Tristetraprolin (TTP) Developmental Biology Diabetes pathways Direct p53 effectors Disease Downregulation of SMAD2/3:SMAD4 transcriptional activity Downstream Signaling Events Of B Cell Receptor (BCR) Downstream signaling in naive CD8+ T cells Downstream signaling of activated FGFR Down-stream signal transduction Downstream signal transduction E-cadherin signaling events E-cadherin signaling in the nascent adherens junction ECM-receptor interaction EGFR1 EGFR-dependent Endothelin signaling events EGFR downregulation EGF receptor (ErbB1) signaling pathway Endocytosis Endogenous TLR signaling Endosomal/Vacuolar pathway Endothelins Energy dependent regulation of mTOR by LKB1-AMPK EphrinB-EPHB pathway EPO signaling pathway Epstein-Barr virus infection ErbB1 downstream signaling ErbB4 signaling events ErbB receptor signaling network ER-Phagosome pathway ethanol degradation IV Extracellular matrix organization Factors involved in megakaryocyte development and platelet production FAS (CD95) signaling pathway Fatty acid, triacylglycerol, and ketone body metabolism Fc-epsilon receptor I signaling in mast cells FGFR1c and Klotho ligand binding and activation Focal adhesion Formation and Maturation of mRNA Transcript Formation of Platelet plug FOXA1 transcription factor network FOXA transcription factor networks FoxO family signaling G1/S Transition G2/M Transition GAB1 signalosome G alpha (12/13) signalling events Gastrin-CREB signalling pathway via PKC and MAPK Gene Expression Generic Transcription Pathway Glucocorticoid receptor regulatory network Glucocorticoid receptor signaling Glypican 1 network Glypican 3 network Glypican pathway GMCSF-mediated signaling events GPVI-mediated activation cascade Grb2 events in EGFR signaling GRB2 events in ERBB2 signaling GRB2:SOS provides linkage to MAPK signaling for Intergrins Hemostasis Hepatitis B Herpes simplex infection HIF-1-alpha transcription factor network HIV-1 Nef: Negative effector of Fas and TNF-alpha HIV Infection Host Interactions of HIV factors HTLV-I infection Hypoxic and oxygen homeostasis regulation of HIF-1-alpha IFN-gamma pathway IGF1 pathway IL12-mediated signaling events IL1-mediated signaling events IL23-mediated signaling events IL2-mediated signaling events IL2 signaling events mediated by PI3K IL2 signaling events mediated by STAT5 IL3-mediated signaling events IL4-mediated signaling events IL5-mediated signaling events Immune System Inflammasomes Influenza A Innate Immune System Innate Immunity Signaling Insulin Pathway Insulin receptor signalling cascade Integration of energy metabolism Integrin alphaIIb beta3 signaling Integrin cell surface interactions Integrin family cell surface interactions Integrins in angiogenesis Interferon alpha/beta signaling Interferon gamma signaling Interferon Signaling Interleukin-2 signaling Interleukin-3, 5 and GM-CSF signaling Internalization of ErbB1 Intrinsic Pathway for Apoptosis Iron uptake and transport IRS-mediated signalling IRS-related events ISG15 antiviral mechanism KitReceptor L1CAM interactions L-cysteine degradation III Leishmaniasis LKB1 signaling events Loss of Nlp from mitotic centrosomes Loss of proteins required for interphase microtubule organization from the centrosome LPA receptor mediated events Maturation of Notch precursor via proteolytic cleavage Mature Notch receptor trafficks to plasma membrane Membrane Trafficking Metabolism Metabolism of amino acids and derivatives Metabolism of lipids and lipoproteins Metabolism of mRNA Metabolism of nucleotides Metabolism of proteins Metabolism of RNA MHC class II antigen presentation mitochondrial L-carnitine shuttle pathway Mitotic G1-G1/S phases Mitotic G2-G2/M phases mRNA Processing mRNA Splicing mRNA Splicing - Major Pathway mTOR signaling pathway mTOR signalling MyD88 cascade initiated on plasma membrane MyD88 dependent cascade initiated on endosome MyD88-independent cascade MyD88-independent cascade initiated on plasma membrane MyD88:Mal cascade initiated on plasma membrane N-cadherin signaling events NCAM1 interactions NCAM signaling for neurite out-growth Nectin adhesion pathway Nef mediated downregulation of MHC class I complex cell surface expression Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Netrin-1 signaling Netrin mediated repulsion signals Neurotrophic factor-mediated Trk receptor signaling NFkB and MAP kinases activation mediated by TLR4 signaling repertoire NGF signalling via TRKA from the plasma membrane N-glycan trimming in the ER and Calnexin/Calreticulin cycle NICD trafficks to nucleus NICD traffics to nucleus Noncanonical Wnt signaling pathway NOSIP mediated eNOS trafficking NOTCH NOTCH1 Intracellular Domain Regulates Transcription Notch-HLH transcription pathway Notch-mediated HES/HEY network Notch receptor binds with a ligand Notch signaling pathway Nuclear Receptor transcription pathway Nuclear signaling by ERBB4 p130Cas linkage to MAPK signaling for integrins p38 MAPK signaling pathway p53 pathway p63 transcription factor network p75(NTR)-mediated signaling PAR1-mediated thrombin signaling events Pathways in cancer PDGFR-alpha signaling pathway PDGFR-beta signaling pathway PDGF receptor signaling network Phagosomal maturation (early endosomal stage) PI3K/AKT activation PI3K/AKT Signaling in Cancer PI3K-Akt signaling pathway PI-3K cascade PI3K Cascade PI3K events in ERBB2 signaling PI3K events in ERBB4 signaling PIP3 activates AKT signaling PKB-mediated events Plasma membrane estrogen receptor signaling Platelet Activation Platelet activation, signaling and aggregation Platelet activation triggers Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Platelet degranulation Platelet homeostasis PLK1 signaling events Polo-like kinase signaling events in the cell cycle Post-translational protein modification Posttranslational regulation of adherens junction stability and dissassembly PPARA Activates Gene Expression Pre-NOTCH Expression and Processing Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Presenilin action in Notch and Wnt signaling Processing of Capped Intron-Containing Pre-mRNA Protein digestion and absorption Proteoglycan syndecan-mediated signaling events Proton-coupled monocarboxylate transport Pyruvate metabolism and Citric Acid (TCA) cycle RAC1 signaling pathway Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor Recruitment of mitotic centrosome proteins and complexes Recycling pathway of L1 Regulation of AMPK activity via LKB1 Regulation of Androgen receptor activity Regulation of CDC42 activity Regulation of cytoplasmic and nuclear SMAD2/3 signaling Regulation of gap junction activity Regulation of Insulin Secretion Regulation of KIT signaling Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Regulation of mRNA Stability by Proteins that Bind AU-rich Elements Regulation of nuclear beta catenin signaling and target gene transcription Regulation of nuclear SMAD2/3 signaling Regulation of p38-alpha and p38-beta Regulation of RAC1 activity Regulation of retinoblastoma protein Regulation of RhoA activity Regulation of signaling by CBL Regulation of Telomerase Response to elevated platelet cytosolic Ca2+ Retinoic acid receptors-mediated signaling RhoA signaling pathway Rho GTPase cycle RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Role of Calcineurin-dependent NFAT signaling in lymphocytes RORA Activates Circadian Expression RXR and RAR heterodimerization with other nuclear receptor S1P1 pathway Semaphorin interactions SHC1 events in EGFR signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Shc events in EGFR signaling SHC-mediated signalling SHC-related events Signaling by Aurora kinases Signaling by EGFR Signaling by EGFR in Cancer Signaling by ERBB2 Signaling by ERBB4 Signaling by FGFR Signaling by FGFR1 amplification mutants Signaling by FGFR1 fusion mutants Signaling by FGFR1 mutants Signaling by FGFR in disease Signaling by GPCR Signaling by Insulin receptor Signaling by Interleukins Signaling by Notch Signaling by NOTCH Signaling by NOTCH1 Signaling by PDGF Signaling by Rho GTPases Signaling by SCF-KIT Signaling by TGF-beta Receptor Complex Signaling by the B Cell Receptor (BCR) Signaling events mediated by focal adhesion kinase Signaling events mediated by HDAC Class I Signaling events mediated by HDAC Class II Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Signaling events mediated by PTP1B Signaling events mediated by Stem cell factor receptor (c-Kit) Signaling events mediated by TCPTP Signaling events mediated by the Hedgehog family Signaling events mediated by VEGFR1 and VEGFR2 Signaling events regulated by Ret tyrosine kinase Signaling in Immune system Signalling by NGF Signalling to ERKs Signalling to RAS Signal Transduction Signal transduction by L1 SOS-mediated signalling Sphingosine 1-phosphate (S1P) pathway Spry regulation of FGF signaling Stabilization and expansion of the E-cadherin adherens junction Sterols are 12-hydroxylated by CYP8B1 sulfite oxidation IV Syndecan-1-mediated signaling events Syndecan-2-mediated signaling events Syndecan-4-mediated signaling events TCR signaling TCR signaling in naive CD4+ T cells TCR signaling in naive CD8+ T cells TGF-beta receptor signaling TGFBR The citric acid (TCA) cycle and respiratory electron transport The NLRP1 inflammasome The role of Nef in HIV-1 replication and disease pathogenesis Thrombin/protease-activated receptor (PAR) pathway Thromboxane A2 receptor signaling Tie2 Signaling Tight junction TNF alpha/NF-kB TNF receptor signaling pathway Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor 9 (TLR9) Cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Receptor Cascades TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TRAF6 Mediated Induction of proinflammatory cytokines TRAIL signaling pathway Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Transcriptional Regulation of White Adipocyte Differentiation Translation Transport of Notch receptor precursor to golgi Trk receptor signaling mediated by PI3K and PLC-gamma Tuberculosis Unfolded Protein Response Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Validated targets of C-MYC transcriptional repression Validated transcriptional targets of AP1 family members Fra1 and Fra2 Validated transcriptional targets of deltaNp63 isoforms Viral carcinogenesis Wnt Wnt signaling network