WORDS
kinase
protein
tyrosine
activation
cells
phosphorylation
signaling
kinases
activated
factor
growth
proteins
signal
cell
activity
map
pathways
pathway
src
phosphorylated
transduction
response
ifn
receptor
ras
transcription
binding
factors
induced
mapk
fig
raf
egf
stimulation
sh2
stimulated
family
usa
department
signals
dependent
serine
university
activate
molecular
domain
jnk
expression
specific
mediated
institute
threonine
dna
two
receptors
jun
erk
cellular
sh3
cascade
phosphotyrosine
mitogen
stat
fos
activates
membrane
addressed
rac
correspondence
results
gene
medical
domains
school
biology
intracellular
rho
akt
mek
responses
control
medicine
required
grb2
treated
regulatory
interferon
research
extracellular
regulated
cytoplasmic
antibody
genes
mammalian
nucleus
pdgf
cancer
residues
creb
vitro
RELATED TOPICS
receptor receptors binding cell ligand
ras gtp protein camp atp
protein cell kinase activity cycle
cell cells tcr receptor cd4
kinase protein tyrosine activation cells
RELATED DOCUMENTS
"Ras-Dependent Growth Factor Regulation of MEK Kinase in PC12 Cells" (1994)
"Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK" (1994)
"A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation" (1998)
"Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element" (1995)
"Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase" (1996)
"Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein" (1995)
"Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation" (1993)
"MAP Kinases: Charting the Regulatory Pathways" (1992)
"A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway" (1997)
"SH2 and SH3 Domains: Elements That Control Interactions of Cytoplasmic Signaling Proteins" (1991)
"The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways" (1993)
"Osmotic Activation of the HOG MAPK Pathway via Ste 11p MAPKKK: Scaffold Role of Pbs2p MAPKK" (1997)
"Stimulatory Effects of Yeast and Mammalian 14-3-3 Proteins of the Raf Protein Kinase" (1994)
"Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase" (1994)
"Trying on a New Pair of SH2s" (1993)
"Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt" (1999)
"Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways" (1997)
"Distinct Protein Targets for Signals Acting at the c-fos Serum Response Element" (1991)
"Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS" (1996)
"MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade" (1998)
"Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase $\gamma$" (1997)
"Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro" (1992)
"Reversal of Raf-1 Activation by Purified and Membrane-Associated Protein Phosphatases" (1995)
"Requirement for MAP Kinase (ERK2) Activity in Interferon $\alpha$- and Interferon $\beta$-Stimulated Gene Expression Through STAT Proteins" (1995)
"Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase" (1992)
"Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway" (1996)
"Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor" (1995)
"Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)" (1999)
"Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses" (1996)
"Routing MAP Kinase Cascades" (1998)
"Positive and Negative Regulation of I$\kappa$B Kinase Activity Through IKK$\beta$ Subunit Phosphorylation" (1999)
"Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase" (1998)
"Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway" (1997)
"Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases" (1996)
"Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2" (1995)
"Effect of Phospholipase C-$\gamma$ Overexpression on PDGF-Induced Second Messengers and Mitogenesis" (1990)
"Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption" (1998)
"STAT3 as an Adapter to Couple Phosphatidylinositol 3-Kinase to the IFNAR1 Chain of the Type I Interferon Receptor" (1997)
"A Common Nuclear Signal Transduction Pathway Activated by Growth Factor and Cytokine Receptors" (1993)
"Requirement for Phosphatidylinositol Transfer Protein in Epidermal Growth Factor Signaling" (1995)
"Interaction of Shc with the $\zeta$ Chain of the T Cell Receptor Upon T Cell Activation" (1993)
"Activation of Transcription by IFN-$\gamma$: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein" (1992)
"Activation of Raf as a Result of Recruitment to the Plasma Membrane" (1994)
"Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt" (1997)
"Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate" (1997)
"Akt Signaling: Linking Membrane Events to Life and Death Decisions" (1997)
"Requirements for Phosphorylation of MAP Kinase During Meiosis in Xenopus Oocytes" (1992)
"An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins" (1994)
"Inhibition of Ras-Induced DNA Synthesis by Expression of the Phosphatase MKP-1" (1994)
"SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases" (1993)
"Induction by EGF and Interferon-$\gamma$ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei" (1993)
"Interaction of the Protein Kinase Raf-1 with 14-3-3 Proteins" (1994)
"Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors" (1996)
"Requirement of Rsk-2 for Epidermal Growth Factor-Activated Phosphorylation of Histone H3" (1999)
"NF-$\kappa$B Activation by Ultraviolet Light Not Dependent on a Nuclear Signal" (1993)
"RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase" (1996)
"Regulation of Interferon-$\gamma$-Activated STAT1 by the Ubiquitin- Proteasome Pathway" (1996)
"An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G$_1$" (1995)
"Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor" (1992)
"Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3',5'-Monophosphate" (1993)
"Targeted Degradation of c-Fos, But Not v-Fos, by a Phosphorylation-Dependent Signal on c-Jun" (1992)
"Yin and Yang of Phosphorylation in Cytokine Signaling" (1993)
"Cell Survival Demands Some Rsk" (1999)
"Requirement of NF-$\kappa$B Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras" (1997)
"Combinatorial Control Required for the Specificity of Yeast MAPK Signaling" (1997)
"Catalysis by a Multiprotein I$\kappa$B Kinase Complex" (1997)
"Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases" (1997)
"Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase" (1995)
"Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx" (1998)
"An Osmosensing Signal Transduction Pathway in Mammalian Cells" (1994)
"Binding of SH2 Domains of Phospholipase C$_\gamma$l, GAP, and Src to Activated Growth Factor Receptors" (1990)
"A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf" (1993)
"In situ Activation Pattern of Drosophila EGF Receptor Pathway during Development" (1997)
"Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway" (1995)
"Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor" (1995)
"Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus" (1993)
"Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription- Dependent and -Independent Mechanisms" (1999)
"Tyrosyl Phosphorylation and Activation of MAP Kinases by p56$^{lck}$" (1992)
"Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C" (1998)
"Inhibition by cAMP of Ras-Dependent Activation of Raf" (1993)
"TAB1: An Activator of the TAK1 MAPKKK in TGF-$\beta$ Signal Transduction" (1996)
"Signal Transduction by Interferon-$\alpha$ Through Arachidonic Acid Metabolism" (1991)
"Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice" (1999)
"Role of Substrates and Products of PI 3-Kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav" (1998)
"Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4" (1993)
"PDGF-Induced Activation of Phospholipase C Is Not Required for Induction of DNA Synthesis" (1990)
"Activation of Phosphatidylinositol-3' Kinase by Src-Family Kinase SH3 Binding to the p85 Subunit" (1994)
"I$\kappa$B Kinase-$\beta$: NF-$\kappa$B Activation and Complex Formation with I$\kappa$B Kinase-$\alpha$ and NIK" (1997)
"Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins" (1994)
"Phosphorylation of c-Src on Tyrosine 527 by Another Protein Tyrosine Kinase" (1991)
"Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44$^{MAPK}$- Dependent Phosphorylation" (1999)
"Ca$^{2+}$-Induced Apoptosis Through Calcineurin Dephosphorylation of BAD" (1999)
"Requirement for the Adapter Protein GRB2 in EGF Receptor Endocytosis" (1996)
"Direct Phosphorylation of I$\kappa$B by IKK$\alpha$ and IKK$\beta$: Discrimination Between Free and NF-$\kappa$B-Bound Substrate" (1998)
"Requirement of CDC42 for Salmonella-Induced Cytoskeletal and Nuclear Responses" (1996)
"Tyrosine Phosphorylation of CD22 During B Cell Activation" (1992)
"Signaling Through Scaffold, Anchoring, and Adaptor Proteins" (1997)
"Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Kinase Binding Sites" (1994)
"$\beta$-Arrestin-Dependent Formation of $\beta_2$ Adrenergic Receptor-Src Protein Kinase Complexes" (1999)
"Growth Factors Induce Phosphorylation of the Na$^+$/H$^+$ Antiporter, a Glycoprotein of 110 kD" (1990)