WORDS
cell
cells
tcr
receptor
cd4
antigen
cd8
activation
cd3
expression
fig
thymocytes
chain
complex
surface
rag
molecules
mhc
selection
cd28
signal
specific
institute
chains
mab
development
mature
peptide
lymphocytes
ctla
expressed
immunology
receptors
signals
signaling
cd45
two
positive
rearrangement
thymus
anti
national
interaction
immunoglobulin
molecule
tcrs
cytoplasmic
tyrosine
function
university
associated
events
usa
mediated
thymic
number
recombination
negative
gene
antibody
medicine
express
mice
lymphocyte
immature
ligands
medical
protein
class
molecular
engagement
induced
variable
genes
department
stimulation
antibodies
self
peripheral
absence
complexes
deficient
maturation
required
phosphorylation
bound
ligand
role
health
transduction
differentiation
presence
early
diversity
major
addressed
affinity
proliferation
correspondence
thymocyte
RELATED TOPICS
receptor receptors binding cell ligand
cell cells tcr receptor cd4
kinase protein tyrosine activation cells
cells cell fig expression human
cells mice cell antigen class
RELATED DOCUMENTS
"Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes" (1993)
"Negative Selection of Precursor Thymocytes Before Their Differentiation into CD4$^+$CD8$^+$ Cells" (1992)
"Inhibition of T Cell Receptor Expression and Function in Immature CD4$^+$ CD8$^+$ Cells by CD4" (1990)
"Role of TCR $\delta$ Chain in T Cell Development and Selection" (1994)
"In Vivo Calcium Elevations in Thymocytes with T Cell Receptors That Are Specific for Self Ligands" (1992)
"Thymocyte Development in the Absence of Pre-T Cell Receptor Extracellular Immunoglobulin Domains" (1998)
"Post-Transcriptional Regulation of Early T Cell Development by T Cell Receptor Signals" (1992)
"Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking" (1991)
"The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells" (1990)
"A Subset of CD4$^+$ Thymocytes Selected by MHC Class I Molecules" (1994)
"Thymic Selection of Cytotoxic T Cells Independent of CD8$\alpha$-Lck Association" (1993)
"Fidelity of T Cell Activation Through Multistep T Cell Receptor $\zeta$ Phosphorylation" (1998)
"Molecular Basis of T Cell Inactivation by CTLA-4" (1998)
"The Immunological Synapse: A Molecular Machine Controlling T Cell Activation" (1999)
"Positive Selection Through a Motif in the $\alpha\beta$ T Cell Receptor" (1998)
"Development of Mature CD8$^+$ Thymocytes: Selection Rather Than Instruction?" (1993)
"Analysis and Expression of a Cloned Pre-T Cell Receptor Gene" (1994)
"Costimulation: Building an Immunological Synapse" (1999)
"A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation" (1998)
"The Role of Ig$\beta$ in Precursor B Cell Transition and Allelic Exclusion" (1995)
"T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains" (1999)
"A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection" (1995)
"How T Cells Count" (1996)
"No Requirement for p56$^{lck}$ in the Antigen-Stimulated Clonal Deletion of Thymocytes" (1992)
"Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases" (1994)
"Rescue of Signaling by a Chimeric Protein Containing the Cytoplasmic Domain of CD45" (1993)
"Regulation of Lineage Commitment Distinct from Positive Selection" (1999)
"ZAP-70 Deficiency in an Autosomal Recessive Form of Severe Combined Immunodeficiency" (1994)
"Regulation of TCR Signaling by CD45 Lacking Transmembrane and Extracellular Domains" (1993)
"$\zeta$ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists" (1995)
"Requirement for Tyrosine Kinase p56$^{lck}$ for Thymic Development of Transgenic $\gamma\delta$ T Cells" (1993)
"Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Ig$\beta$" (1996)
"Dancing the Immunological Two-Step" (1999)
"Structural Mutatations of the T Cell Receptor $\zeta$ Chain and Its Role in T Cell Activation" (1990)
"High-Efficiency Expression and Solubilization of Functional T Cell Antigen Receptor Heterodimers" (1992)
"Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase" (1994)
"Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 $\epsilon$" (1992)
"Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide" (1994)
"Peripheral Selection of the T Cell Repertoire" (1991)
"Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development" (1998)
"T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds" (1996)
"Class-Conscious TCR?" (1999)
"T Cell Development in Mice That Lack the $\zeta$ Chain of the T Cell Antigen Receptor Complex" (1993)
"Activation-Induced Ubiquitination of the T Cell Antigen Receptor" (1992)
"Translating Affinity into Response" (1998)
"Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex" (1996)
"A Role for CD81 in Early T Cell Development" (1996)
"Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form" (1990)
"An $\alpha\beta$ T Cell Receptor Structure at 2.5 $\overset{\circ}{\mathrm A}$ and Its Orientation in the TCR-MHC Complex" (1996)
"Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen" (1998)
"Regulation of B Cell Antigen Receptor Signal Transduction and Phosphorylation by CD45" (1991)
"Requirement for TNF-$\alpha$ and IL-1$\alpha$ in Fetal Thymocyte Commitment and Differentiation" (1995)
"Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling" (1996)
"Uncoupling of Nonreceptor Tyrosine Kinases from PLC-$\gamma$1 in an SLP-76- Deficient T Cell" (1998)
"Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4" (1996)
"STAT5 Interaction with the T Cell Receptor Complex and Stimulation of T Cell Proliferation" (1999)
"Control of MHC Restriction by TCR V$_\alpha$ CDR1 and CDR2" (1996)
"Reexpression of RAG-1 and RAG-2 Genes in Activated Mature Mouse B Cells" (1996)
"Reconstitution of T Cell Receptor $\zeta$-Mediated Calcium Mobilization in Nonlymphoid Cells" (1993)
"The Yin and Yang of T Cell Costimulation" (1995)
"Surface Expression of Two Distinct Functional Antigen Receptors on Human $\gamma\delta$ T Cells" (1993)
"CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation" (1999)
"Rescue of T Cell-Specific V(D)J Recombination in SCID Mice by DNA-Damaging Agents" (1994)
"Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28" (1991)
"Selecting T Cell Receptors with High Affinity for Self-MHC by Decreasing the Contribution of CD8" (1992)
"V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses" (1997)
"Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors" (1991)
"Analysis of Junctional Diversity During B Lymphocyte Development" (1990)
"Location of cAMP-Dependent Protein Kinase Type I with the TCR-CD3 Complex" (1994)
"Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance" (1990)
"An Essential Role for BLNK in Human B Cell Development" (1999)
"Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells" (1999)
"Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation" (1993)
"Lack of N Regions in Antigen Receptor Variable Region Genes of TdT-Deficient Lymphocytes" (1993)
"T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity" (1994)
"Transmembrane Helical Interactions and the Assembly of the T Cell Receptor Complex" (1990)
"Reuse of B Lymphocytes in Germinal Centers" (1997)
"Evidence for Cell-Surface Association Between Fusin and the CD4-gp 120 Complex in Human Cell Lines" (1996)
"Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4" (1995)
"Differential Regulation of HIV-1 Fusion Cofactor Expression by CD28 Costimulation of CD4$^+$ T Cells" (1997)
"Induction by Antigen of Intrathymic Apoptosis of CD4$^+$CD8$^+$ TCR$^{lo}$ Thymocytes in Vivo" (1990)
"Interleukin-7: A Cofactor for V(D)J Rearrangement of the T Cell Receptor $\beta$ Gene" (1993)
"Requirement for Positive Selection of $\gamma\delta$ Receptor-Bearing T Cells" (1991)
"A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP" (1995)
"Negative Regulation of CD45 Protein Tyrosine Phosphatase Activity by Ionomycin in T Cells" (1991)
"RAG Mutations in Human B Cell-Negative SCID" (1996)
"Interaction of the IL-2 Receptor with the src-Family Kinase p56$^{lck}$: Identification of Novel Intermolecular Association" (1991)
"Hyperresponsive B Cells in CD22-Deficient Mice" (1996)
"The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II" (1999)
"TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells" (1999)
"RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination" (1990)
"Requirement for CD8 $\beta$ Chain in Positive Selection of CD8-Lineage T Cells" (1994)
"Coordinate Regulation of RAG1 and RAG2 by Cell Type-Specific DNA Elements 5' of RAG2" (1999)
"Cloning of B7-2: A CTLA-4 Counter-Receptor that Costimulates Human T Cell Proliferation" (1993)
"Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4$^+$ T Cells" (1996)
"Inactivation of Misselected CD8 T Cells by CD8 Gene Methylation and Cell Death" (1999)
"T Cell Receptor Specificity and Diabetes in Nonobese Diabetic Mice" (1993)
"Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn" (1991)
"Differential T Cell Costimulatory Requirements in CD28-Deficient Mice" (1993)
"The B Cell Antigen Receptor Complex: Association of Ig-$\alpha$ and Ig-$\beta$ with Distinct Cytoplasmic Effectors" (1992)