WORDS
ras
gtp
protein
camp
atp
proteins
activity
guanosine
cftr
gap
adenosine
cyclase
gdp
nucleotide
triphosphate
gtpase
cells
fig
bound
adenylyl
hydrolysis
cyclic
monophosphate
exchange
activated
binding
diphosphate
pka
inhibition
activation
stimulated
subunit
guanine
subunits
type
cell
two
effect
heterotrimeric
function
concentrations
department
amp
university
effector
induced
receptor
membrane
stimulation
triphosphatase
signaling
active
dependent
rate
signal
cgmp
inhibited
addition
receptors
transduction
activating
amino
plc
mutant
min
results
response
concentration
forskolin
increase
coupled
toxin
form
increased
second
olfactory
presence
adp
acid
effects
catalytic
specific
cystic
state
fibrosis
phosphate
mediated
mutants
science
regulator
activate
control
release
identified
sensitive
medical
expressed
mutations
p21
regulation
RELATED TOPICS
channel channels ion membrane voltage
ca2 calcium release cells intracellular
ras gtp protein camp atp
protein proteins binding domain membrane
kinase protein tyrosine activation cells
drug receptor dopamine brain receptors
RELATED DOCUMENTS
"Heterogeneous Amino Acids in Ras and Rap1A Specifying Sensitivity to GAP Proteins" (1991)
"Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the Krev-1 Gene Product" (1990)
"A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner" (1990)
"Inhibition of Adenylyl Cyclase by G$_{i\alpha}$" (1993)
"Inhibition of Brain G$_z$ GAP and Other RGS Proteins by Palmitoylation of G Protein $\alpha$ Subunits" (1997)
"Regulation of Ras-GAP and the Neurofibromatosis-1 Gene Product by Eicosanoids" (1991)
"Mechanistic Aspects of Signaling Through Ras in NIH 3T3 Cells" (1992)
"Facilitation of Signal Onset and Termination by Adenylyl Cyclase" (1999)
"A GDP Dissociation Inhibitor That Serves as a GTPase Inhibitor for the Ras-Like Protein CDC42Hs" (1992)
"Regulation of Polyphosphoinositide-Specific Phospholipase C Activity by Purified G$_q$" (1991)
"A Cytosolic Protein Catalyzes the Release of GDP from p21$^{ras}$" (1990)
"GAP into the Breach" (1997)
"Uncoupling of GTP Binding from Target Stimulation by a Single Mutation in the Transducin $\alpha$ Subunit" (1996)
"The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants" (1997)
"A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein $\beta\gamma$ Subunits" (1995)
"There Are GAPS and There Are GAPS" (1997)
"GTP-GDP Exchange Proteins" (1990)
"G$_z$-Mediated Hormonal Inhibition of Cyclic AMP Accumulation" (1992)
"Crystal Structure of the Adenylyl Cyclase Activator G$_{s\alpha}$" (1997)
"Type-Specific Regulation of Adenylyl Cyclase by G Protein $\beta\gamma$ Subunits" (1991)
"Construction of a Soluble Adenylyl Cyclase Activated by G$_s\alpha$ and Forskolin" (1995)
"The Effect of Posttranslational Modifications on the Interaction of Ras2 with Adenylyl Cyclase" (1993)
"Regulation of Adenylyl Cyclase from Paramecium by an Intrinsic Potassium Conductance" (1992)
"Two G Protein Oncogenes in Human Endocrine Tumors" (1990)
"Molecular Basis for Interactions of G Protein $\beta\gamma$ Subunits with Effectors" (1998)
"In Vivo Receptor-Mediated Phosphorylation of a G Protein in Dictyostelium" (1990)
"Separate GTP Binding and GTPase Activating Domains of a G$\alpha$ Subunit" (1993)
"Enhancement of the GDP-GTP Exchange of RAS Proteins by the Carboxyl- Terminal Domain of SCD25" (1990)
"A Family of cAMP-Binding Proteins That Directly Activate Rap1" (1998)
"Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras$\cdot$GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins" (1996)
"Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor" (1993)
"Effect of Deleting the R Domain on CFTR-Generated Chloride Channels" (1991)
"Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation in Animal Cells" (1993)
"Binding of GAP to Activated PDGF Receptors" (1990)
"Requirement of Drosophila NF1 for Activation of Adenylyl Cyclase by PACAP38-Like Neuropeptides" (1997)
"Structures of Active Conformations of G$_{i\alpha1}$ and the Mechanism of GTP Hydrolysis" (1994)
"CFTR as a cAMP-Dependent Regulator of Sodium Channels" (1995)
"Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II" (1996)
"Regulation by ATP and ADP of CFTR Chloride Channels That Contain Mutant Nucleotide-Binding Domains" (1992)
"Role for the Target Enzyme in Deactivation of Photoreceptor G Protein In Vivo" (1998)
"Cystic Fibrosis Transmembrane Conductance Regulator and Adenosine Triphosphate" (1997)
"A Site on Rod G Protein $\alpha$ Subunit That Mediates Effector Activation" (1992)
"GAP Domains Responsible for Ras p21-Dependent Inhibition of Muscarinic Atrial K$^+$ Channel Currents" (1992)
"A G Protein Mutant That Inhibits Thrombin and Purinergic Receptor Activation of Phospholipase A$_2$" (1990)
"The Cellular Functions of Small GTP-Binding Proteins" (1990)
"Regulation of Ion Channels by ABC Transporters That Secrete ATP" (1995)
"Identification of the SH3 Domain of GAP as an Essential Sequence for Ras-GAP-Mediated Signaling" (1993)
"Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G$_{s\alpha}\cdot$GTP$\gamma$S" (1997)
"Suppression of Odorant Responses by Odorants in Olfactory Receptor Cells" (1994)
"Two-Metal-Ion Catalysis in Adenylyl Cyclase" (1999)
"Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code" (1993)
"Dictyostelium Development in the Absence of cAMP" (1997)
"Generation of cAMP-Activated Chloride Currents by Expression of CFTR" (1991)
"Regulation of Cardiac Na$^+$, Ca$^{2+}$ Exchange and K$_{ATP}$ Potassium Channels by PIP$_2$" (1996)
"Common Modifications of Trimeric G. Proteins and ras Protein: Involvement of Polyisoprenylation" (1990)
"Molecular Switch for Signal Transduction: Structural Differences between Active and Inactive Forms of Protooncogenic ras Proteins" (1990)
"Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis" (1992)
"Human Sos1: A Guanine Nucleotide Exchange Factor for Ras That Binds to GRB2" (1993)
"Inhibition of Rap1A Binding to Cytochrome b$_{558}$ of NADPH Oxidase by Phosphorylation of Rap1A" (1991)
"Activation of Exocytosis by the Heterotrimeric G Protein G$_{i3}$" (1993)
"Identity of Inositol 1,2-Cyclic Phosphate 2-Phosphohydrolase with Lipocortin III" (1990)
"Failure of the Cystic Fibrosis Transmembrane Conductance Regulator to Conduct ATP" (1996)
"Associative Learning Disrupted by Impaired G$_s$ Signaling in Drosophila Mushroom Bodies" (1996)
"Orphanin FQ: A Neuropeptide that Activates an Opioidlike G Protein-Coupled Receptor" (1995)
"Selectivity in Signal Transduction Determined by $\gamma$ Subunits of Heterotrimeric G Proteins" (1993)
"Nerve Growth Factor Stimulation of the Ras-Guanine Nucleotide Exchange Factor and GAP Activities" (1992)
"Identification of Small Clusters of Divergent Amino Acids That Mediate the Opposing Effects of ras and Krev-1" (1990)
"G Protein-Coupled Signal Transduction Pathways for Interleukin-8" (1993)
"Resolution of a Signal Transfer Region from a General Binding Domain in G$\beta$ for Stimulation of Phospholipase C-$\beta$2" (1999)
"Deactivation of Visual Transduction Without Guanosine Triphosphate Hydrolysis by G Protein" (1992)
"Activation of a Small GTP-Binding Protein by Nucleoside Diphosphate Kinase" (1991)
"PIP$_2$ and PIP as Determinants for ATP Inhibition of K$_{ATP}$ Channels" (1998)
"Altered Fluid Transport Across Airway Epithelium in Cystic Fibrosis" (1993)
"Receptor and $\beta\gamma$ Binding Sites in the $\alpha$ Subunit of the Retinal G Protein Transducin" (1997)
"G Protein Activation of a Hormone-Stimulated Phosphatase in Human Tumor Cells" (1992)
"A Point Mutation of the $\alpha_2$-Adrenoceptor That Blocks Coupling to Potassium But Not Calcium Currents" (1992)
"Identification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection" (1990)
"Mutations of the Adenylyl Cyclase Gene That Block RAS Function in Saccharomyces cerevisiae" (1990)
"p115 RhoGEF, a GTPase Activating Protein for G$\alpha_{12}$ and G$\alpha_{13}$" (1998)
"Pieces of the True Grail: A G Protein Finds Its Target" (1997)
"Tertiary and Quaternary Structural Changes in G$_{i\alpha 1}$ Induced by GTP Hydrolysis" (1995)
"Reciprocal Stimulation of GTP Hydrolysis by Two Directly Interacting GTPases" (1995)
"A Putative ATP-Activated Na$^+$ Channel Involved in Sperm-Induced Fertilization" (1993)
"Does Diphtheria Toxin Have Nuclease Activity?" (1990)
"Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos" (1998)
"CFTR Chloride Channel Regulation by an Interdomain Interaction" (1999)
"Chloride Conductance Expressed by $\Delta$F508 and Other Mutant CFTRs in Xenopus Oocytes" (1991)
"Suppression of Ras-Induced Transformation of NIH 3T3 Cells by Activated G$\alpha_s$" (1994)
"Internal Lysine Palmitoylation in Adenylate Cyclase Toxin from Bordetella pertussis" (1994)
"The Many Roads That Lead to Ras" (1993)
"In Vivo Functional Analysis of the Ras Exchange Factor Son of Sevenless" (1995)
"RasGRP, a Ras Guanyl Nucleotide-Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs" (1998)
"Tyrosine Kinase-Stimulated Guanine Nucleotide Exchange Activity of Vav in T Cell Activation" (1993)
"Protein Prenylation: A Mediator of Protein-Protein Interactions" (1993)
"Membrane Phospholipid Control of Nucleotide Sensitivity of K$_{ATP}$ Channels" (1998)
"Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes" (1993)
"Nucleoside Diphosphate Kinase: Conclusions Withdrawn" (1992)
"Regulation of Plasma Membrane Recycling by CFTR" (1992)
"Inhibition of Serum- and Ras-Stimulated DNA Synthesis by Antibodies to Phospholipase C" (1990)
"Evidence of a Role for Heterotrimeric GTP-Binding Proteins in Endosome Fusion" (1992)