WORDS
structure
binding
peptide
structural
bound
complex
antibody
design
inhibitors
two
csa
structures
conformation
residues
activity
protein
fk506
site
compounds
cis
fab
trans
affinity
fig
inhibitor
drug
ligands
based
bind
high
molecular
determined
cell
chain
ligand
crystal
side
biological
amide
ray
proteins
pocket
rapamycin
different
three
cyclosporin
inhibit
drugs
molecule
mechanism
analogs
changes
synthetic
active
cyclophilin
agents
target
conformational
cyp
research
immunosuppressive
bond
state
potent
signal
acid
system
enzyme
loop
studies
basis
fkbp
designed
small
inhibition
chemistry
backbone
information
solution
university
found
transduction
abbott
proline
therapeutic
department
form
vol
action
step
recognition
immunophilins
nuclear
addressed
correspondence
specific
shown
activation
conformations
science
RELATED TOPICS
structure binding peptide structural bound
reaction reactions chemical chemistry molecules
protein proteins binding domain membrane
rna dna site structure polymerase
RELATED DOCUMENTS
"A Conformation of Cyclosporin A in Aqueous Environment Revealed by the X-ray Structure of a Cyclosporin-Fab Complex" (1992)
"Receptor-Induced Conformation Change of the Immunosuppressant Cyclosporin A" (1991)
"Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand" (1990)
"Inhibition of FKBP Rotamase Activity by Immunosuppressant FK506: Twisted Amide Surrogate" (1990)
"Isotope-Edited NMR of Cyclosporin A Bound to Cyclophilin: Evidence for a Trans 9,10 Amide Bond" (1990)
"Structure-Based Design of a Cyclophilin-Calcineurin Bridging Ligand" (1993)
"Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands" (1991)
"Rusting of the Lock and Key Model for Protein-Ligand Binding" (1991)
"Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex" (1991)
"Solution Structure of FKBP, a Rotamase Enzyme and Receptor for FK506 and Rapamycin" (1991)
"Structural Evidence for Induced Fit as a Mechanism for Antibody-Antigen Recognition" (1992)
"Discovering High-Affinity Ligands for Proteins: SAR by NMR" (1996)
"Discovering High-Affinity Ligands for Proteins" (1997)
"Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast" (1991)
"Crystal Structures of an Antibody to a Peptide and Its Complex with Peptide Antigen at 2.8 $\AA$" (1990)
"Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors" (1994)
"Association of a 59-Kilodalton Immunophilin with the Glucocorticoid Receptor Complex" (1992)
"Another Piece of the HIV Puzzle Falls into Place" (1992)
"Design and Synthesis of a Mimetic from an Antibody Complementarity- Determining Region" (1991)
"Three-Dimensional Structure of an Angiotensin II-Fab Complex at 3 $\overset{\circ}{\mathrm A}$: Hormone Recognition by an Anti-Idiotypic Antibody" (1992)
"Regulated Delivery of Therapeutic Proteins After In vivo Somatic Cell Gene Transfer" (1999)
"Design, Activity, and 2.8 $\overset{\circ}{A}$ Crystal Structure of a C$_2$ Symmetric Inhibitor Complexed to HIV-1 Protease" (1990)
"Interaction of a Peptidomimetic Aminimide Inhibitor with Elastase" (1995)
"Interaction of the Immunosuppressant Deoxyspergualin with a Member of the Hsp70 Family of Heat Shock Proteins" (1992)
"Controlling Signal Transduction with Synthetic Ligands" (1993)
"Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions" (1994)
"Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors" (1995)
"Phosphorodithioate DNA as a Potential Therapeutic Drug" (1993)
"Structure-Based Strategies for Drug Design and Discovery" (1992)
"Discovery of a Peptide-Based Renin Inhibitor with Oral Bioavailability and Efficacy" (1992)
"Designed Enediynes: A New Class of DNA-Cleaving Molecules with Potent and Selective Anticancer Activity" (1992)
"Structure-Based Discovery of Inhibitors of Thymidylate Synthase" (1993)
"Making Molecular Matches in the Cell" (1993)
"Anatomy of a Conformational Change: Hinged Lid Motion of the Triosephosphate Isomerase Loop" (1990)
"Structural Basis for Phosphotyrosine Peptide Recognition by Protein Tyrosine Phosphatase 1B" (1995)
"Rational Design of Peptide-Based HIV Proteinase Inhibitors" (1990)
"Crystal Structure of the Principal Neutralization Site of HIV-1" (1994)
"Crystal Structure of $\beta$-D-Cellotetraose Hemihydrate with Implications for the Structure of Cellulose II" (1994)
"Structural Insights into the Evolution of an Antibody Combining Site" (1997)
"Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase" (1991)
"An Information-Intensive Approach to the Molecular Pharmacology of Cancer" (1997)
"Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen" (1998)
"Immunological Origins of Binding and Catalysis in a Diels-Alderase Antibody" (1998)
"Metalloantibodies" (1990)
"New Intracellular Targets for Therapeutic Drug Design" (1993)
"Evolutionary Chemistry: Getting There from Here" (1997)
"Modulation of Calmodulin Plasticity in Molecular Recognition on the Basis of X-Ray Structures" (1993)
"Antibody-Catalyzed Rearrangement of the Peptide Bond" (1992)
"Exploiting the Basis of Proline Recognition by SH3 and WW Domains: Design of N-Substituted Inhibitors" (1998)
"Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin" (1998)
"Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules" (1992)
"Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors" (1998)
"Energy Transduction on the Nanosecond Time Scale: Early Structural Events in a Xanthopsin Photocycle" (1998)
"Crystal Structure of a Catalytic Antibody with a Serine Protease Active Site" (1994)
"Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism" (1997)
"Molecular Switch for Signal Transduction: Structural Differences between Active and Inactive Forms of Protooncogenic ras Proteins" (1990)
"Isomerase and Chaperone Activity of Prolyl Isomerase in the Folding of Carbonic Anhydrase" (1992)
"Evolving Catalysts in Real Time" (1996)
"Deconstructing Vancomycin" (1999)
"Design and Synthesis of a Peptide Having Chymotrypsin-Like Esterase Activity" (1990)
"Evolution of Shape Complementarity and Catalytic Efficiency from a Primordial Antibody Template" (1999)
"Novel Fluorogenic Substrates for Assaying Retroviral Proteases by Resonance Energy Transfer" (1990)
"Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor" (1990)
"Fluorescent, Sequence-Selective Peptide Detection by Synthetic Small Molecules" (1998)
"Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23" (1996)
"Minimization of a Polypeptide Hormone" (1995)
"Identification of D-Peptide Ligands Through Mirror-Image Phage Display" (1996)
"Recognition of Angiotensin II: Antibodies at Different Levels of an Idiotypic Network are Superimposable" (1992)
"Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K$^b$" (1992)
"Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance" (1998)
"Routes to Catalysis: Structure of a Catalytic Antibody and Comparison with Its Natural Counterpart" (1994)
"Chemical Characterization of a Family of Brain Lipids That Induce Sleep" (1995)
"Structure of the Amino-Terminal Core Domain of the HIV-1 Capsid Protein" (1996)
"Pharmacological Rescue of Mutant p53 Conformation and Function" (1999)
"Closing in on a Stomach-Sparing Aspirin Substitute" (1996)
"The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II" (1999)
"Structures of Free and Inhibited Human Secretory Phospholipase A$_2$ from Inflammatory Exudate" (1991)
"An Antibody exo Diels-Alderase Inhibitor Complex at 1.95 Angstrom Resolution" (1998)
"Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator" (1999)
"Protease Inhibitors: A Tale of Two Companies" (1996)
"Optical Switching and Image Storage by Means of Azobenzene Liquid-Crystal Films" (1995)
"Specific Binding of Chromosomal Protein HMG1 to DNA Damaged by the Anticancer Drug Cisplatin" (1992)
"Solution Structure of a Calmodulin-Target Peptide Complex by Multidimensional NMR" (1992)
"Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin A" (1999)
"Ligand Binding: Molecular Mechanics Calculation of the Streptavidin-Biotin Rupture Force" (1996)
"Getting Some Backbone: How MHC Binds Peptides" (1992)
"The Immunological Evolution of Catalysis" (1996)
"Retinoids Selective for Retinoid X Receptor Response Pathways" (1992)
"FGF Binding and FGF Receptor Activation by Synthetic Heparan-Derived Di- and Trisaccharides" (1995)
"Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin" (1996)
"Design of a G$\cdot$C-Specific DNA Minor Groove-Binding Peptide" (1994)
"Medium Effects in Antibody-Catalyzed Reactions" (1991)
"High-Resolution Protein Design with Backbone Freedom" (1998)
"At the Crossroads of Chemistry and Immunology: Catalytic Antibodies" (1991)
"Mechanism-Based Inactivation of Prostatic Acid Phosphatase" (1993)
"Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations" (1998)
"Toxic Shock Syndrome Toxin-1 Complexed with a Class II Major Histocompatibility Molecule HLA-DR1" (1994)
"From Molecular Diversity to Catalysis: Lessons from the Immune System" (1995)
"Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp" (1993)
"Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 $\overset{\circ}{\mathrm A}$" (1996)