| RELATED DOCUMENTS |
| "A Conformation of Cyclosporin A in Aqueous Environment Revealed by the X-ray Structure of a Cyclosporin-Fab Complex" (1992) |
| "Receptor-Induced Conformation Change of the Immunosuppressant Cyclosporin A" (1991) |
| "Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand" (1990) |
| "Inhibition of FKBP Rotamase Activity by Immunosuppressant FK506: Twisted Amide Surrogate" (1990) |
| "Isotope-Edited NMR of Cyclosporin A Bound to Cyclophilin: Evidence for a Trans 9,10 Amide Bond" (1990) |
| "Structure-Based Design of a Cyclophilin-Calcineurin Bridging Ligand" (1993) |
| "Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands" (1991) |
| "Rusting of the Lock and Key Model for Protein-Ligand Binding" (1991) |
| "Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex" (1991) |
| "Solution Structure of FKBP, a Rotamase Enzyme and Receptor for FK506 and Rapamycin" (1991) |
| "Structural Evidence for Induced Fit as a Mechanism for Antibody-Antigen Recognition" (1992) |
| "Discovering High-Affinity Ligands for Proteins: SAR by NMR" (1996) |
| "Discovering High-Affinity Ligands for Proteins" (1997) |
| "Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast" (1991) |
| "Crystal Structures of an Antibody to a Peptide and Its Complex with Peptide Antigen at 2.8 $\AA$" (1990) |
| "Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors" (1994) |
| "Association of a 59-Kilodalton Immunophilin with the Glucocorticoid Receptor Complex" (1992) |
| "Another Piece of the HIV Puzzle Falls into Place" (1992) |
| "Design and Synthesis of a Mimetic from an Antibody Complementarity- Determining Region" (1991) |
| "Three-Dimensional Structure of an Angiotensin II-Fab Complex at 3 $\overset{\circ}{\mathrm A}$: Hormone Recognition by an Anti-Idiotypic Antibody" (1992) |
| "Regulated Delivery of Therapeutic Proteins After In vivo Somatic Cell Gene Transfer" (1999) |
| "Design, Activity, and 2.8 $\overset{\circ}{A}$ Crystal Structure of a C$_2$ Symmetric Inhibitor Complexed to HIV-1 Protease" (1990) |
| "Interaction of a Peptidomimetic Aminimide Inhibitor with Elastase" (1995) |
| "Interaction of the Immunosuppressant Deoxyspergualin with a Member of the Hsp70 Family of Heat Shock Proteins" (1992) |
| "Controlling Signal Transduction with Synthetic Ligands" (1993) |
| "Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions" (1994) |
| "Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors" (1995) |
| "Phosphorodithioate DNA as a Potential Therapeutic Drug" (1993) |
| "Structure-Based Strategies for Drug Design and Discovery" (1992) |
| "Discovery of a Peptide-Based Renin Inhibitor with Oral Bioavailability and Efficacy" (1992) |
| "Designed Enediynes: A New Class of DNA-Cleaving Molecules with Potent and Selective Anticancer Activity" (1992) |
| "Structure-Based Discovery of Inhibitors of Thymidylate Synthase" (1993) |
| "Making Molecular Matches in the Cell" (1993) |
| "Anatomy of a Conformational Change: Hinged Lid Motion of the Triosephosphate Isomerase Loop" (1990) |
| "Structural Basis for Phosphotyrosine Peptide Recognition by Protein Tyrosine Phosphatase 1B" (1995) |
| "Rational Design of Peptide-Based HIV Proteinase Inhibitors" (1990) |
| "Crystal Structure of the Principal Neutralization Site of HIV-1" (1994) |
| "Crystal Structure of $\beta$-D-Cellotetraose Hemihydrate with Implications for the Structure of Cellulose II" (1994) |
| "Structural Insights into the Evolution of an Antibody Combining Site" (1997) |
| "Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase" (1991) |
| "An Information-Intensive Approach to the Molecular Pharmacology of Cancer" (1997) |
| "Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen" (1998) |
| "Immunological Origins of Binding and Catalysis in a Diels-Alderase Antibody" (1998) |
| "Metalloantibodies" (1990) |
| "New Intracellular Targets for Therapeutic Drug Design" (1993) |
| "Evolutionary Chemistry: Getting There from Here" (1997) |
| "Modulation of Calmodulin Plasticity in Molecular Recognition on the Basis of X-Ray Structures" (1993) |
| "Antibody-Catalyzed Rearrangement of the Peptide Bond" (1992) |
| "Exploiting the Basis of Proline Recognition by SH3 and WW Domains: Design of N-Substituted Inhibitors" (1998) |
| "Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin" (1998) |
| "Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules" (1992) |
| "Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors" (1998) |
| "Energy Transduction on the Nanosecond Time Scale: Early Structural Events in a Xanthopsin Photocycle" (1998) |
| "Crystal Structure of a Catalytic Antibody with a Serine Protease Active Site" (1994) |
| "Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism" (1997) |
| "Molecular Switch for Signal Transduction: Structural Differences between Active and Inactive Forms of Protooncogenic ras Proteins" (1990) |
| "Isomerase and Chaperone Activity of Prolyl Isomerase in the Folding of Carbonic Anhydrase" (1992) |
| "Evolving Catalysts in Real Time" (1996) |
| "Deconstructing Vancomycin" (1999) |
| "Design and Synthesis of a Peptide Having Chymotrypsin-Like Esterase Activity" (1990) |
| "Evolution of Shape Complementarity and Catalytic Efficiency from a Primordial Antibody Template" (1999) |
| "Novel Fluorogenic Substrates for Assaying Retroviral Proteases by Resonance Energy Transfer" (1990) |
| "Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor" (1990) |
| "Fluorescent, Sequence-Selective Peptide Detection by Synthetic Small Molecules" (1998) |
| "Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23" (1996) |
| "Minimization of a Polypeptide Hormone" (1995) |
| "Identification of D-Peptide Ligands Through Mirror-Image Phage Display" (1996) |
| "Recognition of Angiotensin II: Antibodies at Different Levels of an Idiotypic Network are Superimposable" (1992) |
| "Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K$^b$" (1992) |
| "Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance" (1998) |
| "Routes to Catalysis: Structure of a Catalytic Antibody and Comparison with Its Natural Counterpart" (1994) |
| "Chemical Characterization of a Family of Brain Lipids That Induce Sleep" (1995) |
| "Structure of the Amino-Terminal Core Domain of the HIV-1 Capsid Protein" (1996) |
| "Pharmacological Rescue of Mutant p53 Conformation and Function" (1999) |
| "Closing in on a Stomach-Sparing Aspirin Substitute" (1996) |
| "The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II" (1999) |
| "Structures of Free and Inhibited Human Secretory Phospholipase A$_2$ from Inflammatory Exudate" (1991) |
| "An Antibody exo Diels-Alderase Inhibitor Complex at 1.95 Angstrom Resolution" (1998) |
| "Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator" (1999) |
| "Protease Inhibitors: A Tale of Two Companies" (1996) |
| "Optical Switching and Image Storage by Means of Azobenzene Liquid-Crystal Films" (1995) |
| "Specific Binding of Chromosomal Protein HMG1 to DNA Damaged by the Anticancer Drug Cisplatin" (1992) |
| "Solution Structure of a Calmodulin-Target Peptide Complex by Multidimensional NMR" (1992) |
| "Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin A" (1999) |
| "Ligand Binding: Molecular Mechanics Calculation of the Streptavidin-Biotin Rupture Force" (1996) |
| "Getting Some Backbone: How MHC Binds Peptides" (1992) |
| "The Immunological Evolution of Catalysis" (1996) |
| "Retinoids Selective for Retinoid X Receptor Response Pathways" (1992) |
| "FGF Binding and FGF Receptor Activation by Synthetic Heparan-Derived Di- and Trisaccharides" (1995) |
| "Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin" (1996) |
| "Design of a G$\cdot$C-Specific DNA Minor Groove-Binding Peptide" (1994) |
| "Medium Effects in Antibody-Catalyzed Reactions" (1991) |
| "High-Resolution Protein Design with Backbone Freedom" (1998) |
| "At the Crossroads of Chemistry and Immunology: Catalytic Antibodies" (1991) |
| "Mechanism-Based Inactivation of Prostatic Acid Phosphatase" (1993) |
| "Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations" (1998) |
| "Toxic Shock Syndrome Toxin-1 Complexed with a Class II Major Histocompatibility Molecule HLA-DR1" (1994) |
| "From Molecular Diversity to Catalysis: Lessons from the Immune System" (1995) |
| "Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp" (1993) |
| "Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 $\overset{\circ}{\mathrm A}$" (1996) |