HHsim: Graphical Hodgkin-Huxley Simulator

David S. Touretzky, Mark V. Albert, Nathaniel D. Daw, Alok Ladsariya and Mahtiyar Bonakdarpour

HHsim is a graphical simulation of a section of excitable neuronal membrane using the Hodgkin-Huxley equations. It provides full access to the Hodgkin-Huxley parameters, membrane parameters, stimulus parameters, and ion concentrations. To learn about the Hodgkin-Huxley equations, see: In contrast with NEURON or GENESIS, which are vastly more sophisticated research tools, HHsim is simple educational software designed specifically for graduate or undergraduate neurophysiology courses. The user interface can be mastered in a couple of minutes and provides many ways for the student to experiment.

HHsim is free software distributed under the GNU General Public License. The official HHsim web site is at http://www.cs.cmu.edu/~dst/HHsim. The online documentation, including sample screen shots, is available on this web site, and also included with the program when you download it. Also included are sample exercises that use the simulator.

Download HHsim Now

HHsim is available as a Windows, Mac, or Unix executable file that does not require a Matlab license. Source code is included. It is also available in source-only form if you have Matlab R2007a or later. The latest release of HHsim is version 3.1, released February 16, 2008. Notes for Mac users: (1) HHsim requires that X11 be installed; it's available in /Applications/Utilities/X11.app. (2)There is a known graphics error in Leopard (Mac OS 10.5) that fails to display button labels. We're working on a fix for this; for now, please see the screenshot below for the labels. The functionality is the same.

Version 3.2 - Jan 29, 2012
Version 3.1 - Feb 16, 2008

Version 3.1 - Feb 16, 2008 (obsolete now)

Mac OS X (Intel Architecture)
Version 3.1 - Feb 16, 2008 (obsolete now)

Mac OS X (PowerPC Architecture)
Version 3.1 - Aug 23, 2008 (obsolete now)

Matlab source code only
Version 3.3 - Sept. 9, 2015
hhsim_33_source.zip or browse the code online

Installation Instructions (version 3.1)

Windows: Linux: Mac (Intel Architecture):

Sample screen shot:

Click here for HHsim User's Guide

This work was supported in part by National Science Foundation grant DGE-9987588. Any opinions, conclusions, or recommendations expressed herein are those of the authors and do not necessarily reflect the views of the National Science Foundation.

Dave Touretzky
Last modified: Wed Sep 9 12:37:40 EDT 2015