Newsgroups: comp.ai.genetic
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From: notredame@ebi.ac.uk
Subject: Re: GA en proteins
Sender: news@ebi.ac.uk (Mr news)
Message-ID: <1996Mar6.144946@ebi.ac.uk>
Date: Wed, 6 Mar 1996 14:49:46 GMT
Lines: 36
References: <3136D181.66B4@sins.uia.ac.be>
Organization: European BioInformatics Institute

In article <3136D181.66B4@sins.uia.ac.be>, "Edwin.Schenck" <schenck@sins.uia.ac.be> writes:
> I am a student in computersciene amd i am programming a GA to optimize a
> binclassification in proteins.
> As this is in the pharmaceutical branche, I am very curious if anybody
> else is programming GAs which operate on proteins, DNA , ...
> 
> please email me,
> 		thanks
> 				Edwin Schenck
A few GA have been applied to molecular biology problems, they involve mainly
	-Genomic analyses ( genome mapping)
	-structure determination ( protein folding and RNA folding)
        -Multiple alignment
One of the recent paper about this subject was published in J mol biol, about
the simulation of RNA folding (Gultyaev A.P. and al J. Mol. Biol 1995 (250)
37-51.
In the EBI ( European Bioinformatics Institute) We have also recently 
developped a program designed for making multiple sequence alignment named
SAGA, that is to appear very soon in Nucleic Acid Research ( Notredame and
Higgins, SAGA a genetic Algorithm for multiple sequence alignment (NAR, to
appear)) The paper is available from the authors on request.

There is also a site on the web, dealing with GA and Biological problems such 
 as protein folding  :
http://www.techfak.uni-bielefeld.de/bcd/Curric/ProtEn/contents

hope this helps

cedric

Cedric.Notredame@ebi.ac.uk
EMBL outstation the European Bioinformatics Institute
HINXTON HALL
HINXTON
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