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From: vke@cypress.com (Venkatesh K. Elay)
Subject: Re: GA's and protein folding - any work kno
Message-ID: <1994Sep7.145043.4460@cypress.com>
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Organization: Cypress Semiconductor
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Date: Wed, 7 Sep 1994 14:50:43 GMT
Lines: 31

In article 4tn@news.cerf.net, leb@mitekgold1 (Lars Bernstein) writes:
>Paul Barton-Davis (pauld@cs.washington.edu) wrote:
>: Does anyone know of any work that tries to use GA's for exploring the
>: state space of protein configurations ? Currently, various groups are
>: trying clever tricks to constrain the search space, so that reasonable
>: calculations of energetic optimality can be carried out. It occurs to
>: me that doing this with GA's might be a totally cool way to do this:
>: start with an initial set of random configurations; adjust each one
>: several times to generate a new, larger set; prune based on energetic
>: fitness, and iterate.
>
>: -- paul
>: -- 
>
>When I was working at the San Diego office of BBN Systems and Technologies
>there was a person there who was doing exactly what you describe - using
>a GA to determine minimum energy conformations of molecules.  I don't
>know too much about it now, but I may be able to find out more specifics
>from my old contacts there.
>
>Laurence E. Bernstein
>leb@miteksys.com
>


Also, check with Dr. Koza at Stanford, he has a chapter in his Genetic Programming
II, the next generation, on protein configurations.

-Venkatesh Elayavalli


