Top 10
The top ten charts the articles that have been downloaded most often, in PDF format, from the Nature Genetics website in recent weeks. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.
Top of pageArticle
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
Wellcome Trust Case Control Consortium & The Australo-Anglo-American Spondylitis Consortium (TASC)
doi:10.1038/ng.2007.17
Abstract - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants | Full Text - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants | PDF (364 KB) - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants | Supplementary information - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
Article
Genetic determinants of hair, eye and skin pigmentation in Europeans
Patrick Sulem, Daniel F Gudbjartsson, Simon N Stacey, Agnar Helgason, Thorunn Rafnar, Kristinn P Magnusson, Andrei Manolescu, Ari Karason, Arnar Palsson, Gudmar Thorleifsson, Margret Jakobsdottir, Stacy Steinberg, Snæbjörn Pálsson, Fridbert Jonasson, Bardur Sigurgeirsson, Kristin Thorisdottir, Rafn Ragnarsson, Kristrun R Benediktsdottir, Katja K Aben, Lambertus A Kiemeney, Jon H Olafsson, Jeffrey Gulcher, Augie Kong, Unnur Thorsteinsdottir & Kari Stefansson
doi:10.1038/ng.2007.13
Abstract - Genetic determinants of hair, eye and skin pigmentation in Europeans | Full Text - Genetic determinants of hair, eye and skin pigmentation in Europeans | PDF (269 KB) - Genetic determinants of hair, eye and skin pigmentation in Europeans | Supplementary information - Genetic determinants of hair, eye and skin pigmentation in Europeans
News and Views
Aging and cancer: killing two birds with one worm
Anne Brunet
doi:10.1038/ng1107-1306
Full Text - Aging and cancer: killing two birds with one worm | PDF (178 KB) - Aging and cancer: killing two birds with one worm
See also: Letter by Pinkston-Gosse & Kenyon
Article
Network modeling links breast cancer susceptibility and centrosome dysfunction
Miguel Angel Pujana, Jing-Dong J Han, Lea M Starita, Kristen N Stevens, Muneesh Tewari, Jin Sook Ahn, Gad Rennert, Víctor Moreno, Tomas Kirchhoff, Bert Gold, Volker Assmann, Wael M ElShamy, Jean-François Rual, Douglas Levine, Laura S Rozek, Rebecca S Gelman, Kristin C Gunsalus, Roger A Greenberg, Bijan Sobhian, Nicolas Bertin, Kavitha Venkatesan, Nono Ayivi-Guedehoussou, Xavier Solé, Pilar Hernández, Conxi Lázaro, Katherine L Nathanson, Barbara L Weber, Michael E Cusick, David E Hill, Kenneth Offit, David M Livingston, Stephen B Gruber, Jeffrey D Parvin & Marc Vidal
doi:10.1038/ng.2007.2
Abstract - Network modeling links breast cancer susceptibility and centrosome dysfunction | Full Text - Network modeling links breast cancer susceptibility and centrosome dysfunction | PDF (2,218 KB) - Network modeling links breast cancer susceptibility and centrosome dysfunction | Supplementary information - Network modeling links breast cancer susceptibility and centrosome dysfunction
Meeting Report
A gene harvest revealing the archeology and complexity of human disease
Enrico Petretto, Edison T Liu & Timothy J Aitman
doi:10.1038/ng1107-1299
Abstract - A gene harvest revealing the archeology and complexity of human disease | Full Text - A gene harvest revealing the archeology and complexity of human disease | PDF (210 KB) - A gene harvest revealing the archeology and complexity of human disease
Technical Report
Genome-wide in situ exon capture for selective resequencing
Emily Hodges, Zhenyu Xuan, Vivekanand Balija, Melissa Kramer, Michael N Molla, Steven W Smith, Christina M Middle, Matthew J Rodesch, Thomas J Albert, Gregory J Hannon & W Richard McCombie
doi:10.1038/ng.2007.42
Abstract - Genome-wide in situ exon capture for selective resequencing | Full Text - Genome-wide in situ exon capture for selective resequencing | PDF (376 KB) - Genome-wide in situ exon capture for selective resequencing | Supplementary information - Genome-wide in situ exon capture for selective resequencing
Letter
Recurrent DNA copy number variation in the laboratory mouse
Chris M Egan, Srinath Sridhar, Michael Wigler & Ira M Hall
doi:10.1038/ng.2007.19
Abstract - Recurrent DNA copy number variation in the laboratory mouse | Full Text - Recurrent DNA copy number variation in the laboratory mouse | PDF (721 KB) - Recurrent DNA copy number variation in the laboratory mouse | Supplementary information - Recurrent DNA copy number variation in the laboratory mouse
News and Views
Double Dutch for duplications
Ewan Birney
doi:10.1038/ng1107-1303
Full Text - Double Dutch for duplications | PDF (221 KB) - Double Dutch for duplications
See also: Article by Jiang et al.
Brief Communication
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
Peter Broderick, Luis Carvajal-Carmona, Alan M Pittman, Emily Webb, Kimberley Howarth, Andrew Rowan, Steven Lubbe, Sarah Spain, Kate Sullivan, Sarah Fielding, Emma Jaeger, Jayaram Vijayakrishnan, Zoe Kemp, Maggie Gorman, Ian Chandler, Elli Papaemmanuil, Steven Penegar, Wendy Wood, Gabrielle Sellick, Mobshra Qureshi, Ana Teixeira, Enric Domingo, Ella Barclay, Lynn Martin, Oliver Sieber, members of the CORGI Consortium, David Kerr, Richard Gray, Julian Peto, Jean-Baptiste Cazier, Ian Tomlinson & Richard S Houlston
doi:10.1038/ng.2007.18
Abstract - A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk | Full Text - A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk | PDF (239 KB) - A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk | Supplementary information - A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
Letter
A survey of genetic human cortical gene expression
Amanda J Myers, J Raphael Gibbs, Jennifer A Webster, Kristen Rohrer, Alice Zhao, Lauren Marlowe, Mona Kaleem, Doris Leung, Leslie Bryden, Priti Nath, Victoria L Zismann, Keta Joshipura, Matthew J Huentelman, Diane Hu-Lince, Keith D Coon, David W Craig, John V Pearson, Peter Holmans, Christopher B Heward, Eric M Reiman, Dietrich Stephan & John Hardy
doi:10.1038/ng.2007.16
Abstract - A survey of genetic human cortical gene expression | Full Text - A survey of genetic human cortical gene expression | PDF (286 KB) - A survey of genetic human cortical gene expression | Supplementary information - A survey of genetic human cortical gene expression
